What is MAO?

Monoamine Oxidase (MAO)
You may have heard or ready about the acronym called MAOI. This stands for 'monoamine oxidase inhibitor' and is to inhibit monoamine oxidase that is the primary enzyme within the body that breaks down the DMT compound. So by inhibiting these enzymes the DMT will remain in the body for a much longer period of time.

There are two classes of MAO; MAO-A and MAO-B. Inhibitors act differently on these classes of compounds, inhibitors that act on MAO-A are safer because they are reversible, which means they detach from the MAO-A within 36hrs.

Unlike MAO-B inhibitors that can take up to 2 weeks to be removed from the system, due to the cells requirement to synthesize new enzymes. MAOI’s are typically used to treat depression, Parkinson’s disease, Hodgkin’s lymphoma and others, and are contained within such drugs as Marplan, Moclobemide, Nardil, Procarbazine. https://en.wikipedia.org/wiki/Monoamine_oxidase_inhibitor


There are four main concerns associated with an MAOI:
1. Once the MAOI blocks the MAO enzyme it can let harmful tyramines and tryptamines into the blood stream, which can lead to serious cardiac or psychiatric emergencies. This means a special diet is required in order to remove potential toxins from being ingested into the body.

2. As there are two classes of MAO’s, it is important to know which inhibitor to ingest, know the effects on the body and ensure an appropriate diet is maintained throughout.

3. Interactions with other chemicals being taken, such as blood pressure medication, flu medication, MDMA, SSRI’s can increase the risk of serious issues or even death

4. MAOI's also have profound effects on the brain, which can be felt when taken. Be aware of the effects and how they may be similar or how they differ from other chemicals that you intake into your body.

Due to the way in which the MAOI works on the system it is extremely important to be aware of your diet and eliminate the intake of tryptamines (except for DMT) and especially tyramines. We have not previously raised a risk that tyramines have on the brain and secondary effects on the body, but they significantly impact the regulation of blood pressure, which under some situations can lead to serious issues that require hospitalisation and in extreme cases can lead to death.

Source of MAOI
In order to ingest the MAOI that targets MAO-A, it is safer to ingest a capsulated form of powdered Syrian Rue Seed.

You can quite easily purchase powdered Syrian Rue Seed via eBay and you will only require very small quantities.

Make sure you do your research before taking any MAOIs - they can be deadly.


Note: If you chose to take an MAOI together with DMT, you must understand the risks and manage them effectively - there have been reported deaths due to the use of MAOIs.

What is DMT?

Ever since the vocal presence of Terence McKenna and over 20 years worth of his work with psychedelic compounds, including the extraordinary research of Dr Rick Strassman on near-death and mystical experiences, published in his book: DMT – The Spirit Molecule, there has been an influx of people stepping outside their comfort zone and trying psychedelic compounds in an attempt to gain insights that help them understand more about life and answer fundamental questions relating to existence and reality.

One such compound is and alkaloid called N,N-dimethyltryptamine (DMT), which in its own right has some very unique properties. DMT is a rather simple molecule and builds on a core compound called tryptamine (similar to serotonin and melatonin), it is considered the most powerful psychedelic known to man by Terence McKenna (well beyond psilocybin or MDMA) and what sets it apart from all other psychedelic compounds is that it exists naturally within the human brain, including most plants and mammals according to Dr Rick Strassman. Additionally, there is no conclusive evidence detailing where it is produced within the human brain, although research suggests the pineal gland is responsible. There is also little research to indicate the circumstances that lead to DMT production within the human brain, but theories exist describing its use within the dream state and when we are born and possibly when we die. Ongoing research into DMT will help further unlock the mysteries that surround this chemical compound (https://www.cottonwoodresearch.org/).

DMT may also have some influence in the formation of connections between synapses within the brain (https://www.youtube.com/watch?v=EDYctenkgJo), and the focus of meditation to achieve enlightenment may likely be directly linked to DMT. After all, DMT is just a catalyst to something more profound that cannot yet be defined or explained.

DMT in is extracted form, resembles a crystal formation that is pale in colour. The chemical compound is very stable and can quite easily be extracted from a variety of plant materials.

DMT in its raw form is mostly smoked through vaporizing the crystals, but it can also be dissolved and injected or capsulated and ingested.

Due to the legal issues associated with extracting, possessing and selling DMT, no further information will be provided. The focus of information will be constrained to plant materials that contain DMT. 

It is common knowledge though research conducted by Dr Rick Strassman and others, while DMT  exists within the human brain, it also exists with a large number of plant species and animals. There has been quite a bit of research conducted on a variety of plants in order to identify the percentage of DMT they contain.

These investigations are partly due to the use of specific plant species found within the Amazon rainforest that are used as part of Shamanic rituals for thousands of years. These rituals are based on drinking a brew made from plant material that contains primarily DMT and another chemical compound called monoamine oxidase inhibitor (MAOI), while also containing a large number of other unknown chemical compounds. You can read more about MAO's in other articles.

The Shamanic rituals are often commonly referred to as an Ayahuasca journey, where the name Ayahuasca is the name given to the brew that is ingested.

One of the core plants that contain DMT which is used within Ayahuasca is called Mimosa Hostilis and is known to contain large quantities of DMT within the inner root bark. This material is often referred to as MHRB - "Mimosa Hostilis Root Bark".

MHRB is relatively easy to obtain and prepare for a DMT journey and as it also contains a large percentage of DMT, therefore it will be the focus for most of the articles.